NUCLEOSHELL® PFP HPLC Columns

NUCLEOSHELL® core-shell silica phases for HPLC

NUCLEOSHELL® Core-shell technology provides

• Better resolution at lower back pressure and shorter retention time
• Solid core of silicon dioxide
• Homogeneous shell of porous silica
• Highest efficiency compared to traditional totally porous materials
• Particle size 2.7 µm (core 1.7 µm); specific surface 130 m2/g
• RP 18 and RP 18plus phases are also available with particle size 5 µm (core 3.8 µm); specific surface 90 m2/g
• Lower back pressure also allows use on conventional LC systems
• Pressure stability up to 600 bar

NUCLEOSHELL® PFP

Pentafluorophenylpropyl modification with multi-endcapping, USP L43

Key features:

• Based on core-shell particle technology for fast and efficient HPLC
• Hydrophobic phase with alternative selectivity in comparison to classical C18 modifications
• Suitable for LC/MS
• Separation principle based on 4 retention mechanisms: polar interactions (H bonds), dipole-dipole interactions, π-π interactions, hydrophobic interactions

Technical characteristics:

• Pentafluorophenyl propyl modification, multi-endcapped
• Pore size 90 Å
• Particle size 2.7 μm
• pH stability 1–9
• Carbon content ~ 3 %

Recommended application: Aromatic and unsaturated compounds, phenols, halogenated hydrocarbons, isomers, polar compounds like pharmaceuticals, antibiotics; high retention of basic compounds