NUCLEOSIL® CHIRAL-1
Silica-based phases for HPLC enantiomer separation
Features
- Chiral selector L-hydroxyproline – Cu2+ complexes for enantiomer separation based on ligand exchange · USP L32
- Base material NUCLEOSIL® silica
- Particle size 5 μm
- Pore size 120 Å
Principal interaction mode:
- Formation of ternary mixed-ligand complexes with Cu(II) ions
- Differences in the stability of the diastereomeric complexes cause chromatographic separation.
Eluent in column 0.5 mM copper sulfate solution
Recommended application: enantiomers with two polar functional groups with the correct spacing such as α-amino acids, α-hydroxycarboxylic acids (e.g., lactic acid), N-alkyl-α-amino acids etc.
| Thomas No | Mfr No | Description |
|---|---|---|
| 1152Y58 | 720081.40 | HPLC column (analytical), NUCLEOSIL CHIRAL-1, length: 250 mm, ID: 4mm, USP: L32, 1 Column |
| 1152Z90 | 721188.30 | HPLC guard column (analytical), NUCLEOSIL CHIRAL-1, length: 4 mm, ID: 3mm, USP: L32, 1 guard column |
